Preventing Muscle Loss with Weight Loss

Dr. Jenna Lagana
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5 minutes
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When undergoing significant weight loss, some degree of lean muscle mass loss is inevitable, regardless of whether you're using GLP-1 receptor agonists (GLP-1s) or other methods. Weight loss, in general, can lead to muscle loss, and this is not unique to GLP-1s like compounded semaglutide. The important aspect is to focus on strategies that help maintain and build as much muscle as possible during this process.

Understanding Muscle vs. Fat in the Body: 

Comparing fat to muscle is like comparing apples to oranges. Both are crucial to your body, but they play very different roles and have distinct impacts on your health.

Muscle is metabolically active, meaning it burns more calories at rest compared to fat tissue. Studies show that muscle tissue burns about 6 calories per pound per day at rest, while fat burns only about 2 calories per pound per day. This higher calorie burn helps maintain a healthy weight and improve your metabolic rate - this is also why you may feel the need to eat more as you start to increase muscle mass and decrease fat mass!

Additionally, muscle supports overall strength and physical function, which are important for daily activities and quality of life. Maintenance or increase of muscle mass is particularly important for aging women as this is the primary way to prevent the development of osteoporosis, or weakening of bones. To keep a long story short, muscle is crucial for all things positive in life.

Fat, in contrast, primarily stores energy and acts as a cushion and insulator for the body. While a certain amount of fat is necessary for energy balance and protection, excess fat, especially visceral fat, can lead to various chronic and life threatening health issues. 

When losing weight, it's essential to focus on preserving muscle mass while reducing fat. This is more important than tracking the number on the scale. Muscle loss can slow down metabolism and affect overall strength, making it harder to maintain weight loss and perform daily activities. On the other hand, reducing fat improves body composition and overall health. Fortunately, there are several strategies to help preserve muscle mass as you lose weight, which we’ll discuss in this article.

What to Expect

GLP-1s effectively aid in weight loss and management. While some muscle loss can occur, these medications primarily target and help with reducing body fat. The goal is to minimize muscle loss while achieving fat loss.

Strategies to Preserve Muscle Mass

Integrating strength training with aerobic, or cardio, exercise can help achieve a healthy balance of muscle and fat, optimizing overall body composition and creating a more resilient human.

  • Prioritize Protein: Ensure your diet is rich in protein to support muscle maintenance. Foods like lean meats, fish, and legumes are excellent options. Download our 7-Day Meal Plan for high-protein recipe ideas.
  • Regular Strength Training: Engage in regular resistance training exercises to build and sustain muscle mass.
  • Add in Aerobic Exercise: Combining resistance training with aerobic exercise can help maintain a healthy balance of muscle and fat, optimizing overall body composition.
  • Seek Expert Guidance: Collaborate with healthcare professionals or nutritionists to develop a personalized plan that meets your unique needs. Check out our Alan Meds Resource Center for meal plans, fitness plans, and general recommendations. Also, be sure to visit your Alan Meds Portal for upcoming free nutrition and fitness events.
  • Track Your Progress: Regularly monitor your body composition to make necessary adjustments and ensure you're preserving muscle while losing fat. If you are older than 65 and you are concerned about osteoporosis, you may want to track your body composition through a DEXA scan to evaluate muscle, fat, and bone density. 

Conclusion

Some muscle loss is part of any weight loss process, but there are key strategies that can help you maintain a healthier muscle-to-fat ratio and maximize the benefits of GLP-1s.

By integrating strength training, a protein-rich diet, and regular exercise, you can effectively minimize muscle loss and improve your overall body composition. GLP-1s can support your weight loss journey, and combining them with these strategies will help and enhance your health outcomes.

Sources
The Journal of Clinical Endocrinology & Metabolism: "Effects of GLP-1 Receptor Agonists on Muscle Mass in Type 2 Diabetes Patients".
Hinge Health: "Ozempic and Muscle Loss: How to Preserve Muscle Mass".
Mayo Clinic: "GLP-1 Agonists for Weight Loss: Mechanisms and Side Effects".
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